Despite advances in oncology research, cancer is one of the leading causes of death Mittens worldwide.Thus, there is a demand for the development of more selective and effective antitumor agents.This study showed that A398, a novel podophyllotoxin analogue, was cytotoxic to the HT-29, MCF-7, MOLT-4 and HL-60 tumor cell lines, being less active in h
C19-diterpenoid alkaloids have complex Gift Option and diverse structures, posing great challenges for nuclear magnetic resonance (NMR)-based structural elucidation.Three C19-diterpenoid alkaloids, including taronenine E (1), chasmaconitine (2) and vilmorisine (3), were isolated from the roots of Aconitum taronense Fletcher et Lauener, and analyzed
Abstract Background Most virus detection methods are geared towards the detection of specific single viruses or just a few known targets, and lack the capability to uncover the novel viruses that cause emerging viral infections.To address this issue, we developed a computational method that identifies the conserved viral sequences at the genus leve